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Heat-killed Lactobacillus plantarum L-137 for respiratory health, immune function, and antiviral support
Lactobacillus plantarum is a type of lactic acid bacteria found in a variety of fermented foods. The heat-killed version of a specific strain of this bacteria, L. plantarum L-137 (HK L-137), has been shown to enhance immune activity, support respiratory health, and fight viral infections.[1],[2]
Health benefits of HK L-137
Upper respiratory tract infections (URTIs) – infections affecting the nose, sinuses, and throat – are common during cold and flu season. Illness is also more common during rough patches of physical and/or emotional stress, due to the immunosuppressive effects of these experiences.
In a recent study, however, taking 50 mg of HK L-137 daily for 12 weeks was shown to decrease the incidence, duration, and symptoms of URTIs in adults with psychological and emotional stress.[3]
50 mg of HK L-137 daily for 12 weeks was shown to decrease the incidence, duration, and symptoms of URTIs in adults with psychological and emotional stress.
HK L-137 likely staves off URTIs by increasing the immune signaling molecules (cytokines) interleukin 12 (IL-12) and interferon beta (IFN-β).[4],[5]
HK L-137 further works by modulating the response of white blood cells – the cells responsible for immune responses.[6] Specifically, HK L-137 supports a T cell class known as Th1, which distinctively attacks bacteria and viruses.[7],[8] In another study, 50 mg of HK L-137 taken daily for 12 weeks by adults age 40 and up enhanced T cell proliferation, Th1 levels, and health-related quality of life measures.[9] All of this translates into infection-fighting power.
HK L-137 supports a T cell class known as Th1, which distinctively attacks bacteria and viruses.
Oral HK L-137 has also been shown to protect against influenza A virus infection (flu) in mice.[10] Given that it enhances IFN-β in humans, HK L-137 is hypothesized to likewise protect us against the flu and other viral respiratory infections.[11]
No refrigerator required!
Although it’s prepared from lactic acid bacteria found in fermented food, HK L-137 isn’t a probiotic supplement, per se. HK L-137 hails from a sub-class of dead bacteria known as immunobiotics.
Fermented foods and probiotic supplements work by delivering “good” bacteria to the human digestive tract, where they propagate and yield health-boosting benefits.[12] Because they are heat killed, however, immunobiotics like HK L-137 do not (and cannot) grow in the human digestive tract. HK L-137 instead tonifies the infection-fighting branch of the immune system by activating gut immunity and triggering an immune system response as described above.
The process of heat-killing a probiotic also confers additional benefit: heat denatures the cell membrane, thus protecting the cell wall of HK L-137 from degradation by the digestive enzymes of the human gut.[13]
An additional benefit of immunobiotics like HK L-137 is that unlike their “classic” probiotic peers, they do not require refrigeration and are stable at room temperature. They therefore have a longer shelf life than regular probiotics. Furthermore, because there is no risk of it colonizing within the body, HK L-137 may offer a safer alternative to live probiotics for immune-compromised patients, such as those undergoing chemotherapy.
Conclusion
HK L-137 offers a truly unique approach to supporting the immune system, protecting the respiratory tract, and enhancing resilience to infectious illnesses. It turns out a “dead” bacterium has plenty to offer us during viral respiratory infection season.
More about immunobiotics can be found in this article.
Click here to see References
[1] Murosaki S, et al. Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice. Cancer Immunol Immunother. 2000;49:157-64.
[2] Hirose Y, et al. Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults. J Nutr 2006;136:3069-73.
[3] Yoshitaka H, et al. Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. Jour Nut Sci. 2013;39(2):1-8.
[4] Murosaki S, et al. Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen- specific IgE production by stimulation of IL-12 production in mice. J Allergy Clin Immunol. 1998;102;57-64.
[5] Hirose Y, et al. Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production. Microbiol Immunol. 2010;54:143-51.
[6] Yoshitaka H, et al. Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. Jour Nut Sci. 2013;39(2):1-8.
[7] Torii A, et al. Lactobacillus acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines. Allergol Int. 2007;56:293-301.
[8] Kanzato H, et al. Lactobacillus acidophilus strain L-92 induces apoptosis of antigen-stimulated T cells by modulation dendritic cell function. Immunobiology 2008;213:399-408.
[9] Yoshitaka H, et al. Daily intake of heat-killed lactobacillus plantarum L-137 augments acquired immunity in healthy adults. J Nutr. 2006 Dec;136(12):3069-73.
[10] Maedaab N, et al. Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice. Internat Immunopharmacol. 2009;9(9):1122-5.
[11] Arimori Y, et al. Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs. Immunopharmacol and Immunotoxicol. 2012;34(6):937-43.
[12] Boirivant M, Strober W. The mechanism of action of probiotics. Curr Opin Gastroenterol. 2007;23(6):679-92.
[13] Fujiki T, et al. Enhanced immuno-modulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment. Biosci Biotechnol Biochem. 2012;76:918-22.
The information provided is for educational purposes only. Consult your physician or healthcare provider if you have specific questions before instituting any changes in your daily lifestyle including changes in diet, exercise, and supplement use.
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Dr. Erica Zelfand
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