Supporting female AND male hormonal health with 3,3′-diindolylmethane
The healing power of Brassica vegetables like broccoli, cauliflower, Brussels sprouts, cabbage, and kale comes in large part from the phytochemical indole-3-carbinol (I3C), which naturally breaks down in the gut to a constituent known as 3,3′-diindolylmethane (DIM) (pronounced “dim”).[1] Consumption of cruciferous vegetables is associated with a reduction of inflammation,[2],[3] decreased risk of cardiovascular disease,[4],[5] and even lower risks of certain types of cancer.[6],[7],[8] DIM also supports healthy hormone metabolism and detoxification, and thus can be helpful in alleviating a number of hormonal-related issues in both men and women.
DIM and women
There are different estrogen metabolites in the body, some of which are more estrogenic and potentially harmful, while others are likely more protective.[9] DIM’s primary virtue with regard to women’s health comes from its role in helping the body to make a better balance of the “good estrogen” (2-hydroxy-estrone) compared to the “bad estrogen” (16-alpha-hydroxy-estrone).[10],[11] DIM also has anti-estrogenic activity, competing with estrogen for binding sites on cells and reducing proliferation.[12] By these actions, DIM may help reduce the risk of certain hormone-sensitive cancers.[13],[14] It is important to note, however, that DIM supplements should not be used by pregnant women.[15]
Balancing estrogen types and levels is beneficial in alleviating the symptoms of benign breast ailments (such as fibrocystic breast disease) and premenstrual syndrome (PMS). DIM in particular supports this aim when synergized with the herb chaste berry (Vitex agnus-castus), or vitex, as it’s also commonly known.
Chaste berry acts on the hypothalamic-pituitary-ovarian axis, increasing the production of luteinizing hormone (LH), a hormone produced by the brain to trigger ovulation.
Chaste berry acts on the hypothalamic-pituitary-ovarian axis, increasing the production of luteinizing hormone (LH), a hormone produced by the brain to trigger ovulation.[16] By supporting LH production, chaste berry helps shift the ratio of estrogen to progesterone in the body in favor of progesterone, thus further supporting fertility as well.[17],[18],[19] By directly binding to dopamine receptors, furthermore, chaste berry also helps lower prolactin levels,[20],[21],[22] which in turn can help mitigate breast pain, irregular menstrual cycles, and infertility.
DIM and men
DIM is also of value in the management of issues related to the prostate gland and their associated lower urinary tract symptoms.
Although the focus is often on testosterone when it comes to men’s health, estrogen levels are also important to monitor. Because the two hormones act in balance with one another, estrogen excess can cause symptoms of testosterone insufficiency. Estrogen also affects the growth and differentiation of prostate cells, both directly and indirectly, and thus increases the risk of benign prostatic hyperplasia (BPH).[23]
Because the two hormones act in balance with one another, estrogen excess can cause symptoms of testosterone insufficiency.
By shifting estrogen metabolism to support the “good” form of estrogen and reducing the “bad,” DIM may protect prostate tissue from BPH, prostatic inflammation,[24] and may even prevent cellular changes that can contribute to cancer.[25],[26],[27]
Yet estrogen isn’t the only hormone to watch in men. Dihydrotestosterone (DHT) is derived from testosterone in the body by way of an enzyme known as 5-alpha-reductase. During fetal development, DHT plays an essential role in the development of the prostate gland and penis. Later in life, DHT supports the biological characteristics of males like body hair, deep voice, and increased muscle mass.[28] An excess of DHT, however, contributes to male-pattern baldness and prostate gland enlargement (such as that seen in BPH).[29]
When it comes to prostate health, therefore, DIM works particularly well when used alongside the plant Serenoa repens (saw palmetto).[30] Saw palmetto inhibits 5-alpha-reductase, the enzyme that converts testosterone to DHT, thereby reducing the risk of BPH and other prostate ailments.[31] Saw palmetto has also been shown to reduce estrogen levels in the prostate gland, further benefitting those with BPH.[32]
Minimizing the activity of estrogen and levels of DHT are therefore therapeutic goals in the prevention and management of prostate ailments[33],[34] – goals supported through supplementation with DIM and saw palmetto.
Eat your (DIM-packed) veggies!
So when mom says eat your Brussels sprouts? You may want to take her up on it.
…Or just crack open a bottle of DIM.
Click here to see References
Managing Menopause
How diet, exercise, and nutrition can ease the menopausal transition “I’m still hot, it just comes in flashes.” This slogan makes me smile. It means that we can approach menopause with confidence and with humor, especially with the help of friends! Studies have proven that supportive friends play a major role in helping women…
Whole Herb vs. Standardized Extracts vs. Isolated Bioactive Constituents
When using botanical medicine, which is best? It often seems that dietary supplements come with endless array of options, particularly in an online world where one can find hundreds of choices with a seemingly simple search term such as “probiotics.” Similarly, with vitamins and minerals, we are offered so many forms – not only…
Nrf2, Antioxidant Superhero
Fighting oxidative stress and inflammation with natural substances If you cut up an apple and leave it on the counter, you may notice its white flesh turn to brown. A similar effect happens to our own cells when they’re exposed to unstable molecules known as free radicals. This “rusting,” or “browning” process is called…
