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How Do Antioxidants Support Healing?
Certain foods – including beautifully-marketed “superfoods” – are celebrated for their antioxidant properties. But what does that even mean? What are antioxidants, and why are they important?
What is oxidation? Oxidative stress?
As the name implies, antioxidants fight oxidation. But what is oxidation? Let’s take a closer look:
If you cut up an apple and leave it on the counter for a day or two, its white flesh will turn brown. This “rusting,” or “browning” process is called oxidation.
Oxidation occurs in the body, too. Specifically, oxidation happens when our cells are exposed to unstable molecules known as free radicals.
In many cases, oxidation in the body is a normal and healthy thing. For example, free radicals help us fight off bacteria and viruses.
While oxidation is normal, oxidative stress can do us harm.
When free radicals outnumber antioxidants in the body, we get oxidative stress. Oxidative stress can damage our cells. It can even harm our genetic material (DNA). Over time, oxidative stress can increase the risk for many chronic health issues.
Diseases associated with oxidative stress
- Cancer
- Alzheimer’s disease
- Parkinson’s disease
- Diabetes
- Asthma
- Chronic inflammatory conditions
- Chronic fatigue syndrome
- Cardiovascular disease
Common sources of free radicals and oxidative stress include
- Cigarettes and other nicotine/tobacco products
- Diets high in calories
- Sugar in the diet
- Refined carbohydrates like breads, pastas, potato chips, and cookies
- Charbroiled foods, such as barbequed meats
- Alcohol
- Viral infections
- Not exercising enough
- Obesity
- Certain medications
- Not getting enough good quality sleep
- Emotional and/or physical stress
- Poor liver and digestive health, which compromises detoxification pathways
- Chronic infections (like Lyme disease, Epstein-Barr, and dental infections)
- Air pollution, pesticides, harmful chemicals in the air, and mold
- Radiation
Antioxidants fight oxidative stress
Antioxidant foods and substances help combat oxidative stress. Specifically, antioxidants reduce the damage caused by free radicals. In fact, antioxidants are sometimes called “free radical scavengers.”
The body responds to infections by producing free radicals. These free radicals help keep the body healthy by fighting off the invading bacteria, fungus, or virus. Antioxidants help the immune system and the free radicals continue their important job of fighting off the infection, without causing any “friendly fire” to the healthy, human cells.
For this reason, researchers have proposed that people who eat diets rich in antioxidants may fare better in the face of viruses like SARS-CoV-2 (COVID-19).
(Free radicals are harmful because they have an extra, unpaired electron floating around in their molecular structure. Antioxidants donate an extra electron, creating a pair of electrons, thus making the molecules more stable.)
What foods contain antioxidants?
Researchers conducted a study of over 3,000 foods gathered from across the world. They found that spices and herbs contain some of the most antioxidants. Natural, plant-based (vegan) foods tend to have more antioxidant content than foods made from animals.
Some common, all-time favorite antioxidant foods and nutritional agents include:
Dried herbs
In order of highest to lower antioxidant count:
- Cloves
- Mint
- Allspice
- Cinnamon
- Oregano
- Basil
Berries
In order of highest to lower antioxidant count:
- Blackberries – blackberries have more antioxidants per serving than any other fruit or berry!
- Blueberries – blueberries are #2 on the list of high antioxidant count. They have more than double the number of antioxidants as goji berries and raspberries!
- Goji berries
- Raspberries
- Strawberries
- Cranberries
Fruits
In order of highest to lower antioxidant count:
- Amla (Indian gooseberry), dried – dried Amla contains more than 100 times more antioxidants than pomegranates!
- Plums
- Pomegranate
- While dried fruit tends to have higher antioxidant levels than fresh fruit, it’s also more likely to spike blood sugar levels, contain more calories, and cause gas if sulfur is used as a preservative
Vegetables
In order of highest to lower antioxidant count:
- Artichoke
- Kale
- Cauliflower
- Red cabbage
- Orange bell pepper
- Beets
Nuts and seeds
In order of highest to lower antioxidant count:
- Walnuts – walnuts by far have the highest antioxidant value of other nuts – almost 2.5 times that of pecans, and 4 times that of pistachios and chestnuts!
- Pecans
- Pistachios
- Chestnuts
- Sesame seeds
- Flaxseeds (ground)
Legumes
- Dark chocolate
- Coffee – coffee actually contains more antioxidants than green tea, though it comes with certain other problems that green tea doesn’t (we’ll unpack that in another blog post)
Antioxidant Supplements
- Sulforaphane
- Green tea extract
- Milk thistle
- Gingko biloba
- Alpha lipoic acid
- Olive leaf
- N-acetylcysteine
- Glutathione
- Melatonin
- B-complex vitamins
- Vitamin C
- Greens products
Antioxidant Smoothie Recipe
The easiest way to get more health-boosting antioxidants into your life is through the diet. This recipe contains antioxidant-rich foods like berries, parsley, and kale for a tasty treat. The almond butter adds some healthy fat and protein, to help fill you up and give you energy for your day. The kale will make the smoothie turn green – but don’t worry, it will still taste sweet from the berries.
Antioxidant Smoothie Recipe
Equipment
- 1 blender
Ingredients
- ½ cup blackberries fresh or frozen
- ½ cup blueberries fresh or frozen
- ½ cup raspberries strawberries, or cherries (fresh or frozen)
- 1 medium banana peeled (fresh or frozen)
- 2 tablespoons almond butter
- 1 handful fresh parsley
- 2 leaves of kale rinsed, stem and thick ribs discarded
- 2 cup unsweetened nut milk or coconut milk or coconut water (Can use more liquid if for a thinner smoothie)
- 2 ice cubes skip if using frozen berries
Instructions
- Mix all of the ingredients together in a blender.
- Blend on high until ingredients are well combined.
- Add water or other liquid as needed until desired consistency is reached
Nutrition
Just about everyone could stand to get a little antioxidant boost. Thankfully, there are plenty of options to choose from.
References
Click here to see ReferencesGupta RK, et al. Oxidative stress and antioxidants in disease and cancer: a review. Asian Pac J Cancer Prev. 2014;15(11):4405-9.
Sohel MMH, et al. Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway. Cell Tissue Res. 2018 Jul 21.
Mandal A, et al. Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways. Nutrients. 2017 Apr 28;9(5).
Husain H, et al. Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation. Sci Rep. 2018 Jun 5;8(1):8606.
Priftis A, et al. Cell‑specific and roasting‑dependent regulation of the Keap1/Nrf2 pathway by coffee extracts. Mol Med Rep. 2018 Jun;17(6):8325-8331.
Volz N, et al. Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo. J Agric Food Chem. 2012 Sep 26;60(38):9631-41.
Kalthoff S, et al. Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology. 2010 Nov;139(5):1699-710, 1710.
Na HK, Surh YJ. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol. 2008 Apr;46(4):1271-8.
Surai PF. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants (Basel). 2015 Mar 20;4(1):204-47.
Arafa Keshk W, et al. Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer. Chem Biol Interact. 2017 Aug 1;273:266-272.
Liu XP, et al. Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. Life Sci. 2007 Apr 3;80(17):1586-91.
Chen JS, et al. Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis. 2011 Feb;214(2):301-9.
Suh JH, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3381-6.
Fayez AM, et al. Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats. Biomed Pharmacother. 2018 Sep;105:428-433.
Yuan JJ, et al. Enzymatic hydrolysis of oleuropein from Olea europea (olive) leaf extract and antioxidant activities. Molecules. 2015 Feb 11;20(2):2903-21.
Carlsten C, et al. Anti-oxidant N-acetylcysteine diminishes diesel exhaust-induced increased airway responsiveness in person with airway hyper-reactivity. Toxicol Sci. 2014 Jun;139(2):479-87.
Hejrati A, et al. Association of coronavirus pathogencity with the level of antioxidants and immune system. Journal of family medicine and primary care. 2021;10(2):609-14.
Carlsen MH, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J. 2010 Jan 22;9:3.
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What are Antioxidants?
Dr. Erica Zelfand
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