Vaccine Efficacy, Part 1 of 2: Can a Healthy Diet Improve It?
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The influence of dietary fiber, prebiotics, beta-glucan, and fucoidan
Vaccines are one of the greatest successes of modern medicine, helping to protect entire populations against a wide range of infectious diseases.
A vaccine works by training the immune system to recognize and combat pathogens, either viruses or bacteria. To do this, certain molecules (antigens) from the pathogen are typically introduced into the body to trigger immune cells to produce antibodies.
Unfortunately, even with the best of vaccines, not everyone responds adequately to immunization. Inadequate responses can leave people unknowingly susceptible to new infections even if they are immunized, and may also compromise the achievement of herd immunity in the population.
The efficacy of influenza vaccination, for example, ranges from 20% to 90%, depending on age, study population, and vaccine type. As many as one in four individuals under age 65, and half of those over age 65, do not produce enough antibodies to protect against future infections.
Numerous factors influence whether a particular individual will respond adequately to immunization, including the gut microbiota (the collection of microbes that inhabit the gut.),, A healthy microbiota is correlated with a healthy immune response, both to natural infections and vaccines.
In this article we discuss the importance of the microbiota and the influence of dietary fiber, prebiotics, beta-glucan, and fucoidan on vaccine efficacy, and in Part 2 we’ll examine the role of probiotic and synbiotic (prebiotic + probiotic) interventions. Later, we also take a look at the effects of aging (also discussed in a related article about melatonin), and whether immunosenescence can be improved through diet and nutritional measures.
How the microbiota impacts immunity
When the microbiota is healthy it is capable of modulating vaccine efficacy, acting almost like an ‘adjuvant’ to boost vaccine responses.
Billions of microbes inhabit the large intestine, and they strongly influence our health. This community of microbes interacts directly and indirectly with immune cells, influencing the response to infections as well as vaccines., The gut microbiota influences immune responses not only in the gut, but also in the lungs and other organs.,,
Surprisingly, when the microbiota is healthy it is capable of modulating vaccine efficacy, acting almost like an ‘adjuvant’ to boost vaccine responses., Conversely, when the microbiota is disrupted by antibiotics that kill off normal healthy bacteria, the entire immune system is compromised.,,
A loss of beneficial bacteria also occurs with low-fiber diets, with many chronic conditions including obesity,, and with aging itself., The resulting “dysbiosis” can raise the risk of various infections, and also reduce vaccine efficacy.,,
On the positive side, regardless of age or comorbidities, the health of the microbiota can be improved with better diets and targeted nutrition. This often translates to better immunity and vaccine efficacy, as we discuss below.,,
Dietary fiber improves immune responses
Increasing fruit and vegetable intake from two to five servings a day was shown to boost the response to a pneumonia vaccine substantially.
High fiber diets can lower the risk for many diseases, including obesity, diabetes, heart disease, and infections.,, Experts advise that adults consume at least 21 to 38 grams of fiber daily, depending on age and gender.,, Unfortunately, 95% of Americans do not achieve these recommended intakes.
Inadequate fiber intakes are associated with a risk of gut dysbiosis and inadequate immune responses,,,, while high-fiber diets increase the abundance of beneficial bacterial species that generate valuable nutrients, including short-chain fatty acids (SCFAs).,, SCFAs help keep the intestinal wall healthy and they also support the immune system throughout the body.,,, SCFAs are required for optimal health, but their production is frequently limited by the lack of fermentable fiber in the diet.,
Increasing one’s fiber intake may reduce mortality from respiratory and infectious diseases, as well as mortality from all causes for that matter. A survey of over 500,000 adults concluded that every 10 gram-per-day increase in dietary fiber intake could lower the risk of death from infectious diseases by 30 to 40%.
Higher dietary fiber intakes may also improve vaccine efficacy. A randomized controlled trial in elderly volunteers, aged 65 to 85, showed that increasing fruit and vegetable (FV) intakes from two to five (three ounce) servings a day could boost the response to a pneumonia vaccine substantially. In fact, just a single serving more a day was predicted to boost the protective antibody response nearly 20%. (For the study, the FV diet was consumed for 12 weeks prior to vaccination and for four weeks after the vaccine was administered.)
In addition to the extensive benefits one may derive from fiber in general, a certain subcategory of fiber known as fermentable fibers, or prebiotics, will be discussed next.
Prebiotics nourish the microbiota
Certain fermentable fibers have been shown to improve vaccine efficacy in animal models and in humans.
Dietary fibers that are fermentable are known as prebiotics, meaning they support the growth of healthy (probiotic) bacteria. In recent years, these fibers have been isolated, characterized, and used to prepare nutritional supplements.
The connection between prebiotics and immunity was clearly demonstrated in a study published in the influential peer-reviewed medical journal Immunity. The authors raised mice on either a high-fiber (HF) diet containing inulin (a fermentable fiber, or prebiotic) or a control diet. The HF diet stimulated the growth of beneficial bacteria in the gut, increased the production of SCFAs, and stimulated white blood cell (WBC) formation in the bone marrow.
The mice were then exposed to influenza virus to generate an infection. In mice fed the HF diet, infection-fighting WBCs found in the lungs had greater antiviral capacity compared to those in control (low-fiber-diet) mice. The mice given the HF diet also had less lung damage and a greater survival rate. The authors note, “By tuning down excessive innate [immune] responses, promoting tissue-protective mechanisms, and stimulating specific adaptive immunity, dietary fiber and SCFAs can create an immune balance that ultimately protects against disease.”
Inulin, and many other prebiotic fiber supplements, have been shown to support the growth of healthy gut bacteria and the production of SCFAs to varying degrees.,,, Additional prebiotics that can be found in foods as well as supplements include fructooligosaccharides (FOS), galactooligosaccharides (GOS), resistant starch, hemicellulose (arabinoxylan), xylooligosaccharides, and β-glucans; and these are just a few.
Certain prebiotics have been shown to improve vaccine efficacy in animal models,,,, and in humans.,,, In one placebo-controlled trial, healthy young adults were supplemented with a prebiotic (long-chain inulin) for two weeks, and were vaccinated against hepatitis B after seven days. On average, the prebiotic group developed higher antibody titers than the placebo group.52 Large clinical trials are needed to validate these findings.
Beyond influencing the microbiota, one class of prebiotics gets high marks when it comes to vaccine strategies, and that is β-glucan.
The special case of beta-glucan
Yeast β-glucan is under investigation as a vaccine adjuvant, as it stimulates antibody production without any known side effects.
β-glucan is a type of polysaccharide found naturally in fungi, including mushrooms and edible yeast (Saccharomyces cerevisiae),,, and in cereal grains such as oats and barley. The two main types are β-1,3-1,6-glucans (in fungi and yeast) and β-1,3-1,4-glucans (in cereal grains.)
Both types of β-glucans are fermentable,, but the structures found in fungi make them much stronger immunomodulators., In fact, fungal β-glucans are unique among prebiotic fibers, as they directly activate the immune system. Many of the health benefits of medicinal mushrooms are attributable to the presence of these immunomodulatory β-glucans.,
The reason why immune cells recognize certain β-glucans is quite fascinating. The human immune system is designed to recognize pathogens that might cause infections. To this end, one of the ‘foreign’ molecules that immune cells recognize is β-1,3-1,6-glucan, which is present in the cell walls of yeast including Candida spp.,, Although certain Candida spp. are considered normal flora in our digestive tract and on numerous epithelial surfaces, it is highly problematic if it enters our blood stream, and warrants an immune response.
Immune cells have receptors that can immediately recognize the β-glucan molecular structure and take action to neutralize the perceived threat.,, As a bonus, yeast and mushroom β-glucans induce “trained immunity,” a kind of programming of immune cells that confers protection against unrelated infectious agents the body might encounter., In essence, the β-glucan acts as a decoy that fools the immune system into thinking there is a real invader, thus launching the protective immune response. However, β-glucan from food sources is non-toxic and non-infectious.
In animal models, yeast or mushroom β-glucans have been shown to protect against bacterial, parasitic, fungal, and viral infections,,, including influenza., In randomized controlled trials in healthy adults, supplemental yeast β-glucan has also been shown to reduce the severity of upper respiratory tract infections.,,,
Importantly, the immune response triggered by yeast and mushroom β-glucan additionally may improve vaccine responses, as shown in animals.,, Yeast β-glucan is even under investigation as a vaccine adjuvant for humans, as it stimulates antibody production without any known side effects.,,, Most β-glucan supplements are prepared from baker’s yeast, S. cerevisiae, which is orally available. As a functional food, yeast β-glucan is listed under the Generally Recognized As Safe (GRAS) category.
Supplementation with fucoidan for a month prior to vaccination was shown to nearly double the likelihood of achieving protection against future influenza outbreaks.
One more natural product deserves attention here, and that is fucoidan, a polysaccharide derived from seaweed.,, Fucoidans do not have prebiotic properties, but they modulate the immune system in a manner not unlike that of fungal β-glucans.,, However, research suggests that fucoidan and β-glucan have additive effects, suggesting they could be used simultaneously.
Fucoidan has been shown to boost innate and adaptive immunity against viruses, bacteria, and vaccines in animal models.,,, In a randomized, placebo-controlled trial of subjects over the age of 60, supplemental fucoidan (300 mg daily for four weeks) was shown to improve the response to a seasonal flu vaccine. In fact, supplementation with fucoidan for a month prior to vaccination was shown to nearly double the likelihood of achieving protection against future influenza outbreaks. Fucoidans have been discussed at length in regard to their immune and antimicrobial properties here, as well as in an interview with PhD chemist, Helen Fitton, who has studied fucoidans and bioactive compounds found in seaweed for many years.
In sum, improving the microbiota through dietary fiber intake can improve overall immunity and vaccine responses. Supplemental prebiotics that are readily fermentable may accelerate this process. Additionally, β-glucan derived from yeast or mushrooms – and fucoidan from seaweed – have direct effects on immune cells, suggesting the possibility of improving vaccine responses through supplementation.
For more on nutrition and vaccine efficacy, stay tuned for these upcoming articles:
 Vetter V, et al. Understanding modern-day vaccines: what you need to know. Ann Med. 2018 Mar;50(2):110-20.
 Goodwin K, et al. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine. 2006 Feb 20;24(8):1159-69.
 Zimmerman P, Curtis N. Factors that influence the immune response to vaccination. Clin Microbiol Rev. 2019 Mar 13;32(2):e00084-18.
 Ciabattini A, et al. Role of the microbiota in the modulation of vaccine immune responses. Front Microbiol. 2019 Jul 3;10:1305.
 Shelly A, et al. Impact of microbiota: a paradigm for evolving herd immunity against viral diseases. Viruses. 2020 Oct 10;12(10):1150.
 Zimmerman P, Curtis N. The influence of the intestinal microbiome on vaccine responses. Vaccine. 2018 Jul 16;36(30):4433-9.
 Marchesi JR, et al. The gut microbiota and host health: a new clinical frontier. Gut. 2016 Feb;65(2):330-9.
 Zhao T, et al. Influence of gut microbiota on mucosal IgA antibody response to the polio vaccine. NPJ Vaccines. 2020 Jun 9;5:47.
 Wypych TP, et al. The influence of the microbiome on respiratory health. Nat Immunol. 2019 Oct;20(10):1279-90.
 Desselberger U. The mammalian intestinal microbiome: composition, interaction with the immune system, significance for vaccine efficacy, and potential for disease therapy. Pathogens. 2018 Jun 21;7(3):57.
 Abt MC, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 2012 Jul 27;37(1):158-70.
 Minton K. Microbiota: a ‘natural’ vaccine adjuvant. Nature Rev Immunol. 2014 Sep 19;14(10):650.
 Oh JZ, et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity. 2014 Sep 18;41(3):478-92.
 Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1(Suppl 1):4554-61.
 Grayson MH, et al. Intestinal microbiota disruption reduces regulatory T cells and increases respiratory viral infection mortality through increased IFNγ production. Front Immunol. 2018 Jul 10;9:1587.
 Deehan EC, Walter J. The fiber gap and the disappearing gut microbiome: implications for human nutrition. Trends Endocrinol Metab. 2016 May;27(5):239-42.
 Sheridan PA, et al. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes (Lond). 2012 Aug;36(8):1072-7.
 Nave H, et al. Obesity-related immunodeficiency in patients with pandemic influenza H1N1. Lancet Infect Dis. 2011 Jan;11(1):14-5.
 Salazar N, et al. Age-associated changes in gut microbiota and dietary components related with the immune system in adulthood and old age: a cross-sectional study. Nutrients. 2019 Jul 31;11(8):1765.
 Cianci R, et al. The interplay between immunosenescence and microbiota in the efficacy of vaccines. Vaccines (Basel). 2020 Nov 2;8(4):636.
 Yu B, et al. Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice. Hum Vaccin Immunother. 2015;11(5):1140-6.
 Macbeth J, Hsiao A. A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae. bioRxiv. 2019 Jan 1:730796.
 de Jong SE, et al. The impact of the microbiome on immunity to vaccination in humans. Cell Host Microbe. 2020 Aug 12;28(2):169-79.
 Leshem A, et al. The gut microbiome and individual-specific responses to diet. mSystems. 2020 Sep 29;5(5):e00665-20.
 Zelaya H, et al. Respiratory antiviral immunity and immunobiotics: beneficial effects on inflammation-coagulation interaction during influenza virus infection. Front Immunol. 2016 Dec 23;7:633.
 Garcia-Castillo V, et al. Alveolar macrophages are key players in the modulation of the respiratory antiviral immunity induced by orally administered Lacticaseibacillus rhamnosus CRL1505. Front Immunol. 2020 Sep 29;11:568636.
 Quagliani D, Felt-Gunderson P. Closing America’s fiber intake gap: communication strategies from a Food and Fiber Summit. Am J Lifestyle Med. 2016 Jul 7;11(1):80-5.
 Reynolds A, et al. Carbohydrate quality and human health: a series of systematic reviews and meta-analyses. Lancet. 2019 Feb 2;393(10170):434-45.
 Makki K, et al. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe. 2018 Jun 13;23(6):705-15.
 Knudsen KEB, et al. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients. 2018 Oct 13;10(10):1499.
 Siracusa F, et al. Dietary habits and intestinal immunity: from food intake to CD4 + T H Cells. Front Immunol. 2019 Jan 15;9:3177.
 Statovci D, et al. The impact of Western diet and nutrients on the microbiota and immune response at mucosal interfaces. Front Immunol. 2017 Jul 28;8:838.
 Cui J, et al. Dietary fibers from fruits and vegetables and their health benefits via modulation of gut microbiota. Comp Rev Food Sci Food Safety. 2019 Sep;18(5):1514-32.
 Schulthess J, et al. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity. 2019 Feb 19;50(2):432-45.
 Kim M, et al. Gut microbial metabolites fuel host antibody responses. Cell Host Microbe. 2016 Aug 10;20(2):202-14.
 Hooper LV, et al. Interactions between the microbiota and the immune system. Science. 2012 Jun 8;336(6086):1268-73.
 Antunes KH, et al. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat Commun. 2019 Jul 22;10(1):3273.
 Dang AT, Marsland BJ. Microbes, metabolites, and the gut-lung axis. Mucosal Immunol. 2019 Jul;12(4):843-50.
 Baxter NT, et al. Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers. mBio. 2019 Jan 29;10(1):e02566-18.
 Cuervo A, et al. Fiber from a regular diet is directly associated with fecal short-chain fatty acid concentrations in the elderly. Nutr Res. 2013 Oct;33(10):811-6.
 Park Y, et al. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011 Jun 27;171(12):1061-8.
 Gibson A, et al. Effect of fruit and vegetable consumption on immune function in older people: a randomized controlled trial. Am J Clin Nutr. 2012 Dec;96(6):1429-36.
 Carlson JL, et al. Health effects and sources of prebiotic dietary fiber. Curr Dev Nutr. 2018 Jan 29;2(3):nzy005.
 Trompette A, et al. Dietary fiber confers protection against flu by shaping Ly6c− patrolling monocyte hematopoiesis and CD8+ T cell metabolism. Immunity. 2018 May 15;48(5):992-1005.
 Holscher HD. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes. 2017 Mar 4;8(2):172-84.
 Lordan C, et al. Potential for enriching next-generation health-promoting gut bacteria through prebiotics and other dietary components. Gut Microbes. 2020;11(1):1-20.
 So D, et al. Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. Am J Clin Nutr. 2018 Jun 1;107(6):965-83.
 Xiao L, et al. The combination of 2′-fucosyllactose with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides that enhance influenza vaccine responses is associated with mucosal immune regulation in mice. J Nutr. 2019 May 1;149(5):856-69.
 Benyacoub J. Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice. J Nutr. 2008 Jan;138(1):123-9.
 van’t Land B, et al. Regulatory T-cells have a prominent role in the immune modulated vaccine response by specific oligosaccharides. Vaccine. 2010 Aug 9;28(35):5711-7.
 Schijf MA, et al. Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice. PLoS One. 2013 Sep 20;8(9):e75148.
 Vogt LM, et al. Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B. Mol Nutr Food Res. 2017 Oct;61(10).
 Langkamp-Henken B, et al. Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors. J Am Geriatr Soc. 2004 Jan;52(1):3-12.
 Akatsu H, et al. Enhanced vaccination effect against influenza by prebiotics in elderly patients receiving enteral nutrition. Geriatr Gerontol Int. 2016 Feb;16(2):205-13.
 Nagafuchi F, et al. Effects of a formula containing two types of prebiotics, bifidogenic growth stimulator and galacto-oligosaccharide, and fermented milk products on intestinal microbiota and antibody response to influenza vaccine in elderly patients: a randomized controlled trial. Pharmaceuticals (Basel). 2015 Jun 18;8(2):351-65.
 Guggenheim AG, et al. Immune modulation from five major mushrooms: application to integrative oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44.
 Gudi R, et al. Pretreatment with yeast-derived complex dietary polysaccharides suppresses gut inflammation, alters the microbiota composition, and increases immune regulatory short-chain fatty acid production in C57BL/6 mice. J Nutr. 2020 May 1;150(5):1291-302.
 Stier H, et al. Immune-modulatory effects of dietary yeast beta-1,3/1,6-D-glucan. Nutr J. 2014 Apr 28;13:38.
 Nakashima A, et al. β-Glucan in foods and its physiological functions. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):8-17.
 Joyce SA, et al. The cholesterol-lowering effect of oats and oat beta glucan: modes of action and potential role of bile acids and the microbiome. Frontiers in Nutrition. 2019 Nov 27;6:171.
 Jayachandran M, et al. A critical review on health promoting benefits of edible mushrooms through gut microbiota. Int J Mol Sci. 2017 Sep 8;18(9):1934.
 Adams EL, et al. Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. J Pharmacol Exp Ther. 2008 Apr;325(1):115-23.
 Han B, et al. Structure-functional activity relationship of β-glucans from the perspective of immunomodulation: a mini-review. Front Immunol. 2020 Apr 22;11:658.
 Mitsou EK, et al. Effects of rich in β-glucans edible mushrooms on aging gut microbiota characteristics: an in vitro study. Molecules. 2020 Jun 18;25(12):2806.
 Chen J, Seviour R. Medicinal importance of fungal beta-(1–>3), (1–>6)-glucans. Mycol Res. 2007 Jun;111(Pt 6):635-52.
 Ruiz-Herrera J, Ortiz-Castellanos L. Cell wall glucans of fungi. A review. The Cell Surface. 2019 Dec 1;5:100022.
 Sem X, et al. β-glucan exposure on the fungal cell wall tightly correlates with competitive fitness of Candida species in the mouse gastrointestinal tract. Front Cell Infect Microbiol. 2016 Dec 22;6:186.
 Ifrim DC, et al. Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway. J Immunol. 2013 Apr 15;190(8):4129-35.
 Brown GD, et al. Dectin-1 is a major beta-glucan receptor on macrophages. J Exp Med. 2002 Aug 5;196(3):407-12.
 Agrawal S, et al. Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses. PloS one. 2010 Oct 18;5(10):e13418.
 van der Meer JWM, et al. Trained immunity: a smart way to enhance innate immune defence. Mol Immunol. 2015 Nov;68(1):40-4.
 Rice PJ, et al. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther. 2005 Sep;314(3):1079-86.
 De Marco Castro E, et al. β‐1,3/1,6‐glucans and immunity: state of the art and future directions. Mol Nutr Food Res. 2020 Mar 3:1901071.
 Moorlag JCFM, et al. β-glucan induces protective trained immunity against Mycobacterium tuberculosis infection: a key role for IL-1. Cell Rep. 2020 May 19;31(7):107634.
 Liu M, et al. Immune responses induced by heat killed Saccharomyces cerevisiae: a vaccine against fungal infection. Vaccine. 2011 Feb 17;29(9):1745-53.
 Dos Santos JC, et al. β-glucan-induced trained immunity protects against Leishmania braziliensis infection: a crucial role for IL-32. Cell Rep. 2019 Sep 3;28(10):2659-72.
 Muramatsu D, et al. β-Glucan derived from Aureobasidium pullulans is effective for the prevention of influenza in mice. PLoS One. 2012;7(7):e41399.
 Vetvicka V, Vetvickova J. Glucan supplementation enhances the immune response against an influenza challenge in mice. Ann Transl Med. 2015 Feb;3(2):22.
 Fuller R, et al. Yeast-derived β-1,3/1,6 glucan, upper respiratory tract infection and innate immunity in older adults. Nutrition. Jul-Aug 2017;39-40:30-5.
 Talbott SM, Talbott JA. Baker’s yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women. J Am Coll Nutr. 2012 Aug;31(4):295-300.
 Graubaum HJ, et al. A double-blind, randomized, placebo-controlled nutritional study using an insoluble yeast beta-glucan to improve the immune defense system. Food Nutr Sci. 2012 Jun 20;2012.
 Dharsono T, et al. Effects of yeast (1,3)-(1,6)-beta-glucan on severity of upper respiratory tract infections: a double-blind, randomized, placebo-controlled study in healthy subjects. J Am Coll Nutr. 2019 Jan;38(1):40-50.
 Horst G, et al. Effects of beta-1,3-glucan (AletaTM) on vaccination response in broiler chickens. Poult Sci. 2019 Apr 1;98(4):1643-7.
 Wang J, et al. beta-Glucan oligosaccharide enhances CD8(+) T cells immune response induced by a DNA vaccine encoding hepatitis B virus core antigen. J Biomed Biotechnol. 2010;2010:645213.
 Soares E, et al. Glucan particles are a powerful adjuvant for the HbsAg, favoring antiviral immunity. Mol Pharm. 2019 May 6;16(5):1971-81.
 Vetvicka V, et al. β-glucan as a new tool in vaccine development. Scand J Immunol. 2020 Feb;91(2):e12833.
 Jin Y, et al. β-glucans as potential immunoadjuvants: a review on the adjuvanticity, structure-activity relationship and receptor recognition properties. Vaccine. 2018 Aug 23;36(35):5235-44.
 Abraham A, et al. A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens. Clin Exp Immunol. 2019 Nov;198(2):143-52.
 De Smet R, et al. β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination. J Control Release. 2013 Dec 28;172(3):671-8.
 Vetvicka V, Vetvickova J. A comparison of injected and orally administered β-glucans. JANA. 2008;11(1):42-9.
 Beta Glucan Research. GRAS classification of beta-1,3/1,6-glucan or beta-1,3(D)-glucan [Internet]. Available from: https://www.betaglucan.org/fdagras/
 Ale MT, Meyer AS. Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation. RSC Advances. 2013;3(22):8131-41.
 Luthuli S, et al. Therapeutic effects of fucoidan: a review on recent studies. Mar Drugs. 2019 Aug 21;17(9):487.
 Lin Z, et al. Molecular targets and related biologic activities of fucoidan: a review. Mar Drugs. 2020 Jul 22;18(8):376.
 Gotteland M, et al. The pros and cons of using algal polysaccharides as prebiotics. Front Nutr. 2020 Sep 22;7:163.
 Brennan J, et al. Carbohydrate recognition by a natural killer cell receptor, Ly-49C. J Biol Chem. 1995 Apr 28;270(17):9691-4.
 Halling B, et al. Evaluation of the immunomodulatory in vivo activity of Laminaria Hyperborea fucoidan relative to commercial (1, 3/1, 6)-β-d-glucans from yeast and mushrooms. J Nutr Health Sci. 2015;2(2).
 Myers SP, et al. A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex. Biologics. 2011;5:45-60.
 Richards C, et al. Oral fucoidan attenuates lung pathology and clinical signs in a severe influenza a mouse model. Mar Drugs. 2020 May 8;18(5):246.
 Krylova NV, et al. The comparative analysis of antiviral activity of native and modified fucoidans from brown algae Fucus evanescens in vitro and in vivo. Mar Drugs. 2020 Apr 22;18(4):224.
 Hwang PA, et al. Dietary supplementation with low-molecular-weight fucoidan enhances innate and adaptive immune responses and protects against Mycoplasma pneumoniae antigen stimulation. Mar Drugs. 2019 Mar 18;17(3):175.
 Kuznetsova TA, et al. Immunoadjuvant activity of fucoidans from the brown alga Fucus evanescens. Mar Drugs. 2020 Mar 11;18(3):155.
 Negishi H, et al. Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. J Nutr. 2013 Nov;143(11):1794-8.
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Marina MacDonald, MS, PhD
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